Theobromin double salts.



:- ;..licylates of sodium and lithium.

1 been thus obtained of theobromin with for- UNrrED f sTA Es PATENT oFFroE.

. CARL MEZGER AND ALBERT WELLER, or FRAN KI ORT-ON-THEMAIN, GERMANY, ASSIGNORS "r0 VEREINIGTE CHININFABRIKEN ZIMME & 00;. e. M. B. 11,. socm'rr OF GERMANY.

rrmoBRoMm noUBLn sALr's.

Q Specification of Letters Patent.

' Application filed April 4, 1908. Seria1 No. -125,121.

To all whom itmay concemf Be it known that we, CARL MEZGER and ALBERT WELLER, subjects of the German Emperor, andresidents at Frankfort-on-the Main, Germany, have invented certain new and useful Improvements in Theobromin Double Salts, of which the followingis a specification.

v The manufacture" of double salts of theobromin, which are more easily soluble in water than free theobromin, has hitherto. been effected by combining theobrornin-sodium with molecular proportions of alkali salts of organic acids, double salts' having mates, acetates, lactates, benzoates, and

We have now discovered that very'eiii. cient double salts of theobromin can be roduced by the molecular combination of t eo- 'hromin-sodium with halogen salts of the alkalies, such double salts being, for instance, theobromin sodium sodium chlorid, theol)romin-sodium-sodium-bromid, and theobromi'n sodium sodium iodid. All these compounds have the advantage of being i readily soluble in water and the sodium chlorid double salt is distinguished by its high; contents intheobromin, which'is higher than 5 in any other similar preparation, and it has, l inthere cuties, the further advantage that l the theo )romin can act without the addition of an acid foreign to the human body. Other salts, for instance the sodium-hromldl and sodium-iodid double salts, contain, ini addition to theobr'omin, other substances which in this combination have a special i beneficial therapeutical action.

The preparation is carried out by causing theobromin-sodium to act in molecular pro- 5 portions on' the different halogen salts of an alkali. The following are examples of how this invention may be carried out, but the invention is not limited thereto. The parts i are by weight.

Example I: 18 parts of.theobrornin are 3 dissolved in amoderately concentrated solution, of 4 parts of caustic' soda in about 25 parts of water. To this solution 5.85 parts 2 of pure sodium chlorid are added.' The solution is filtered, if, necessar and is evaporated to -dryness, and the drie residue is round.

Exam-flail: 20.2 parts of dr the'o rominsodium, prepared in the usua manner, are

dissolved, together a ithf15,parts of sodiumiodid, in as little W ater as possible, the soluis pulverized.

varied an in lieu of the halogen salts of potassium bromid, can combined .vr-ith the theobromin-alkah compounds.

The theobromin-halogn alkali double salts Patented April 6, ..19( )9.'

tion is evaporated to dryness and-the residue form white powders having an alkal'ine re-., action and a-bitter taste.- .They readfly dis;

solve in Water andvdilute alkalies, butane decomposed by acids, theobromin being thefe by separated. By means of the usual reagents the halogen containedtherein (iodin,

bromin, or chlorin), can be'easilyascertained,

v hile the contents in potassium, or sodium,

can also b'e' ascertained by suitable reactions.

All the salts are insoluble ether, benzolin, and benzene. They are very difiicultly' soluble in absolute alcohol, even if boiling, but are readily soluble in dilute alcohol and glycerin, especially if heat be applied.

We claim: I

1. The herein descrlbed processof making theobromin double salts which consists in' causing theobromin sodium in solution and a halogen salt of an alkali to react on each 7 other in molecular proportions.

2. 'As an article of manufacture thEObI'O-r min halogen alkali double salts, 'forming white powders. having an alkaline reaction and a bitter taste readily dissolving in water and dilute alkalies but being decomposed by acids, thobromin being thereby separat In testimony whereof we have signed our names to this specification in the'presence of two subscribing v. itnesses. CARL MEZGER.

ALBERT \Vitnesses: I

JEAN GRUND, CARI. GRUND. 

